2021 AOSSM-AANA Combined Annual Meeting Recordings-Post Traumatic Osteoarthritis Progression is Diminished by Early Mechanical Unloading in Mice.

Post Traumatic Osteoarthritis Progression is Diminished by Early Mechanical Unloading in Mice.

Video Transcription

Video Summary

In this video presentation, the speaker discusses a study on post-traumatic osteoarthritis and the impact of early mechanical unloading in a mouse model. The study focuses on ACL injuries, which often lead to joint degeneration. The speaker explains the inflammatory cascade that occurs after an ACL injury and the lack of consensus on activity modification post-injury. The idea of unloading the joint came from a discussion in the department, and the speaker explores whether unloading can mitigate the inflammatory response and reduce long-term cartilage degeneration. The study involves loading mice's tibias to overload the joint and rupture the ACL, and then unloading their hind limbs using a pulley system. The mice are monitored for protease activity, synovitis, trabecular bone loss, and osteophyte formation. The results show reduced protease activity and synovitis in the unloaded limbs compared to the control group. Additionally, there is less trabecular bone loss and reduced osteophyte formation in the unloaded limbs. The speaker concludes that early mechanical unloading can reduce inflammation and potentially have long-term effects in reducing post-traumatic osteoarthritis progression. They thank the forum, Anna, AOSSM, their team, and the funding organizations.

Asset Caption

Cassandra Lee, MD

Keywords

post-traumatic osteoarthritis

early mechanical unloading

ACL injuries

inflammatory cascade

joint degeneration