2021 AOSSM-AANA Combined Annual Meeting Recordings-Mechano-Activated Drug Delivery of Growth Factors as a Novel Platform for Enhancing Cartilage Regeneration

Mechano-Activated Drug Delivery of Growth Factors as a Novel Platform for Enhancing Cartilage Regeneration

Video Transcription

Video Summary

In this video, an individual named Nicholas presents a proposal for a partnership between the University of Pennsylvania and a spin-out company called McKenna Therapeutics. The proposal focuses on improving cartilage integration in cartilage repair procedures by using a unique delivery system called mechanoactivated microcapsules (MAMCs). These MAMCs are designed to rupture and release therapeutic payloads when mechanical force is applied, allowing for controlled and targeted delivery for stimulating cartilage regeneration. The proposal aims to fabricate MAMCs with a therapeutic (FGF18) and evaluate their efficacy in enhancing cartilage regeneration and integrative strength. The study will use an ex vivo experimental model and measure outcomes such as mechanical testing, biochemical and histological analysis. The proposal also mentions the team's expertise in cartilage biology, orthopedic surgery, sports medicine, mechanobiology, and chemical and mechanical engineering. If successful, this technology has the potential to revolutionize cartilage regeneration for cartilage repair procedures.

Asset Caption

Nicholas DePhilippo, MD

Keywords

MAMCs

cartilage regeneration

therapeutic payloads

mechanical testing

ex vivo experimental model