2018 Orthobiologics Surgical Skills Online-9

Video Transcription
Video Summary
In this video, the speaker discusses platelet-rich plasma (PRP) and its potential applications in medicine. They suggest that instead of focusing on what PRP is, it is more important to explore what PRP could do for patients. The speaker highlights that there are indications in which PRP has shown efficacy, such as lateral epicondylitis, and emphasizes the importance of conducting thorough research to optimize PRP use for different conditions. They present findings from their own research on tendinopathy and the behavior of stem cells in tendons. They discuss how PRP formulations have not shown outstanding results for stimulating these abnormal cells and promoting tissue regeneration. However, they mention promising early data on bone marrow aspirate concentrate (BMAC) and the potential benefits of using other blood proteins, such as alpha-2 macroglobulin (A2M), to increase the anti-inflammatory capacity of PRP. The speaker also briefly touches on the topic of muscle injuries and the lack of evidence for PRP in this area. They conclude by stating that a flexible system that allows for the synthesis of multiple PRP formulations may be the best approach in clinics. The video then transitions to another speaker, Arne Kaplan, who provides an overview of mesenchymal signaling cells and their potential role in cellular therapy.
Keywords
platelet-rich plasma
PRP
medicine
tendinopathy
stem cells