2018 Orthobiologics Surgical Skills Online-13 - OthroBiologics and Catrilage Repair by Rachel M. Frank, MD

13 - OthroBiologics and Catrilage Repair by Rachel M. Frank, MD

Video Transcription

Video Summary

In this video, Rachel Frank discusses the use of orthobiologics in cartilage repair. She explains that cartilage pathology is common and that not all cartilage lesions require treatment. Frank explores the role of orthobiologics in the treatment of cartilage defects, such as disease modification, prevention of further deterioration, and as an adjunct to cartilage restoration. She mentions some types of orthobiologics used, including platelet-rich plasma (PRP), bone marrow-derived mesenchymal stem cells (MSCs), and adipose-derived cells. Frank presents several animal and human studies that suggest the potential benefits of using orthobiologics, such as improved outcomes in cartilage repair surgery and better patient-reported outcome scores. However, she emphasizes the need for more clinical data and highlights the limitations of current evidence, which is mostly based on low levels of evidence and focuses on osteoarthritis rather than focal chondral defects. Overall, Frank suggests that orthobiologics may be promising, but further research is needed to fully understand their effectiveness in cartilage repair.

Keywords

orthobiologics

cartilage repair

disease modification

platelet-rich plasma

mesenchymal stem cells