Spring 2020 Fellows Webinars-Inflammation in Tendinopathy: Implications for Treatment

Video Transcription

Video Summary

In this video, Jeff Abrams, an assistant professor at Stanford, discusses the inflammatory nature of tendinopathy and the implications for treatment. He highlights the frustration of traditional treatments and the prevalence of tendinopathy, with billions of dollars spent annually on treatment in the US. Abrams delves into the three compartments related to tendinopathy and their role in the inflammatory process. He discusses the stimulation of tenocytes in the stromal compartment, activation of mast cells in the immune sensing compartment, and the influx of immune cells in the infiltrating compartment. Abrams also explores the role of cytokines, such as IL-1 beta, IL-33, and IL-6, in tendinopathy. IL-1 beta has negative effects on tenocytes, IL-33 is responsible for increased collagen-3 presence, and IL-6 can lead to increased collagen production. The video suggests that targeting inflammation and these pathways may lead to innovative treatments for tendinopathy. It also highlights the importance of exercise-based treatments and mentions other modalities like corticosteroid injections, PRP, shockwave therapy, and laser therapy. The video emphasizes the need for more effective treatment options and discusses ongoing research, including the use of microRNAs and cellular therapies. Overall, it provides an informative overview of tendinopathy and potential treatments.

Asset Subtitle

May 4, 2020

Keywords

tendinopathy

inflammatory nature

traditional treatments

prevalence

cytokines

IL-1 beta

IL-33

IL-6

exercise-based treatments

innovative treatments