IC 303-2023: 'Hype, Promise, and Reality: Orthopedic Use of Biologics in 2023'-IC 303 - 'Hype, Promise, and Reality: Orthopedic Use of Biologics in 2023' (4/5)

IC 303 - 'Hype, Promise, and Reality: Orthopedic Use of Biologics in 2023' (4/5)

Video Transcription

Video Summary

The video discusses the potential of cell therapy in tissue repair, with a specific focus on tendon repair. The speaker acknowledges the great potential of cell therapy in promoting tissue healing but also emphasizes that many of these therapies are not yet ready for widespread use. The video explains how cells, such as those derived from adipose or bone marrow, produce signaling molecules that stimulate various biological activities, including cell proliferation, matrix synthesis, chemotaxis, and angiogenesis. However, it is highlighted that there is limited data suggesting that the cells we inject actually engraft in the healing tissue. The video also discusses different sources of cells, such as bone marrow, adipose tissue, and perinatal tissues, and their potential in tendon repair. The speaker emphasizes the need for better characterization of cells used in therapy and the importance of identifying biomarkers to evaluate their composition and biologic activity. Furthermore, the video provides an overview of ongoing clinical trials and future possibilities in cell therapy, such as the use of exosomes and gene therapy approaches.

Asset Caption

Scott Rodeo, MD

Keywords

cell therapy

tissue repair

tendon repair

adipose cells

bone marrow cells

perinatal tissues