IC 302-2022: Hype, Promise, and Reality: Orthopedic Use of Biologics in 2022-Hype, Promise, and Reality: Orthopedic Use of Biologics in 2022 (1/5)

Video Transcription

Video Summary

The video discusses the role of biologic augmentation in rotator cuff tendon repair. The speaker highlights that while techniques to improve biologic events in tissue repair show potential, they are not yet ready for widespread use. The indiscriminate use of unproven therapies may hinder progress in the field. The speaker suggests that clinicians should start by identifying the biologic targets they are trying to treat and consider the different therapies available. They emphasize the importance of rigorously defining the composition and biologic activity of these agents. The speaker mentions various cell-based preparations that are currently used, such as cells derived from bone marrow, peripheral blood, and adipose tissue, but acknowledges that there are limitations and unknowns in this area. The video also discusses the use of platelet-rich plasma (PRP) and autologous blood products in rotator cuff repair, with mixed results and inconclusive evidence. The speaker suggests the need for further study and the development of rapid point-of-care methods to harvest and process cells. They also mention the potential of exosomes and stimulating intrinsic progenitor cells in tissue regeneration. The video concludes with recommendations for post-injection treatment protocols and considerations for systemic factors that may affect healing. Overall, more research is needed to fully understand and optimize the use of biologic augmentation in rotator cuff tendon repair.

Asset Caption

Scott Rodeo, MD

Keywords

biologic augmentation

rotator cuff tendon repair

tissue repair

cell-based preparations

platelet-rich plasma

tissue regeneration