CC2023: The Biological Use of Platelet-Rich Plasma in Skeletal Muscle Injury and Repair (April 2023)-The Biological Use of Platelet-Rich Plasma in Skeletal Muscle Injury and Repair (April 2023)

The Biological Use of Platelet-Rich Plasma in Skeletal Muscle Injury and Repair (April 2023)

Pdf Summary

Platelet-rich plasma (PRP) is a blood product that contains growth factors and active proteins that are thought to assist in the repair of injured tissues and treat pain. Recent studies have investigated the use of PRP in muscle healing, both in vitro and clinically. PRP is prepared by drawing blood from a patient and processing it using commercial preparation kits. The benefits of PRP in orthopedics and sports medicine, including the repair of injured skeletal muscle, have been widely recommended. PRP has been found to promote tissue healing by inducing the release of growth factors and exosomes, which play a role in the coagulation cascade, angiogenesis, and the proliferation and differentiation of stem cells. The concentration of growth factors in PRP decreases over time, which may limit its efficacy. Activation methods, such as electrical stimulation and photostimulation, have been explored to increase growth factor release. The use of lyophilization to create PRP powder has also been investigated as a way to store PRP at room temperature for extended periods while maintaining growth factor concentrations. PRP has been used for pain relief in muscle injuries, but its effectiveness varies among studies. It has also been explored for its potential to enhance muscle regeneration and functional repair through angiogenesis and innervation. However, further research is needed to fully understand the mechanisms and optimize the clinical applications of PRP in muscle healing.

Keywords

Platelet-rich plasma

PRP

blood product

growth factors

active proteins

injured tissues

pain treatment

muscle healing

orthopedics

sports medicine