false
Catalog
CC2022: Relative Efficacy of Intra-articular Injec ...
Relative Efficacy of Intra-articular Injections in ...
Relative Efficacy of Intra-articular Injections in the Treatment of Knee Osteoarthritis: A Systematic Review and Network Meta-analysis (September 2022)
Back to course
Pdf Summary
This systematic review and network meta-analysis assessed the efficacy of different intra-articular injections for the treatment of knee osteoarthritis. The study included randomized controlled trials with a minimum 6-month follow-up and compared the effects of hyaluronic acid (HA), corticosteroids (CS), platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), and placebo on patient-reported outcomes.<br /><br />The results showed that all intra-articular treatments, except corticosteroids, resulted in a statistically significant improvement in outcomes compared with placebo. PRP demonstrated the highest probability of efficacy and had a clinically meaningful difference in function-related improvement compared with CS and placebo. PRGF also showed significant improvement compared with placebo, particularly in pain evaluation. HA had a lower probability of efficacy compared with PRP and PRGF.<br /><br />The study concluded that PRP yielded improved outcomes compared with PRGF, HA, CS, and placebo for the treatment of knee osteoarthritis at a minimum 6-month follow-up. The findings highlight the potential of PRP as a non-operative treatment option for knee osteoarthritis. Further investigations are needed to better understand the long-term efficacy and outcomes of non-surgical management options for knee osteoarthritis.
Keywords
systematic review
network meta-analysis
intra-articular injections
knee osteoarthritis
hyaluronic acid
corticosteroids
platelet-rich plasma
plasma rich in growth factors
placebo
patient-reported outcomes
×
Please select your language
1
English