CC2022: Allograft Versus Autograft Osteochondral Transplant for Chondral Defects of the Talus: Systematic Review and Meta-analysis (October 2022)-Allograft Versus Autograft Osteochondral Transplant for Chondral Defects of the Talus: Systematic Review and Meta-analysis (October 2022)

Allograft Versus Autograft Osteochondral Transplant for Chondral Defects of the Talus: Systematic Review and Meta-analysis (October 2022)

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This systematic review and meta-analysis compared the outcomes of allografts and autografts in osteochondral transplant for chondral defects of the talus. A total of 40 studies with 1,174 procedures were included, with a mean follow-up of 46.5 months. The main outcomes of interest were patient-reported outcome measures (PROMs), MRI findings, and complications.<br /><br />The results showed that at the last follow-up, the autograft group had better scores in the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score (mean difference, 10.5; p = 0.04) and the American Orthopaedic Foot and Ankle Society (AOFAS) score (mean difference, 4.8; p = 0.04) compared to the allograft group. However, there was no significant difference in visual analog scale (VAS) scores between the two groups (p = 0.4). The autograft group also had lower rates of revision surgery (odds ratio, 7.2; p < 0.0001) and failure (odds ratio, 5.1; p < 0.0001) at the last follow-up.<br /><br />Based on these findings, the study concluded that talar osteochondral transplant using autografts was associated with lower rates of failure and revision compared to allografts at midterm follow-up. However, the limited number of studies and the retrospective design of most included studies were identified as limitations of the present analysis. Further high-quality comparative studies are needed to strengthen the evidence in this area.

Keywords

allografts

autografts

osteochondral transplant

chondral defects

talus

patient-reported outcome measures

MOCART score

AOFAS score

revision surgery

failure