CC2021: Clinical Effectiveness of Intraoperative Tranexamic Acid Use in Shoulder Surgery (September 2021)-CC2021: Clinical Effectiveness of Intraoperative Tranexamic Acid Use in Shoulder Surgery (September 2021)

CC2021: Clinical Effectiveness of Intraoperative Tranexamic Acid Use in Shoulder Surgery (September 2021)

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This systematic review and meta-analysis aimed to investigate the clinical effectiveness of tranexamic acid (TXA) in shoulder surgery. The analysis included a total of eight randomized controlled trials, with data from seven of these studies pooled in the meta-analysis. The results showed that TXA was effective in reducing perioperative bleeding in shoulder surgery. There was a significant reduction in total blood loss and postoperative blood loss as measured by drain output in patients who received TXA compared to controls. Hemoglobin reduction was also reduced but not statistically significant. However, when arthroscopic procedures were excluded from the analysis, a statistically significant reduction in hemoglobin reduction was observed. There were no significant differences between the TXA and control groups in terms of postoperative pain, operative time, length of stay, or the need for blood transfusions. The findings of this review support the use of TXA in shoulder surgery to reduce perioperative blood loss. Larger randomized controlled trials with low risk of bias are needed to further evaluate the effectiveness of TXA in specific surgical shoulder procedures.

Keywords

systematic review

meta-analysis

tranexamic acid

TXA

shoulder surgery

clinical effectiveness

perioperative bleeding

total blood loss

postoperative blood loss

hemoglobin reduction