AOSSM 2023 Annual Meeting Recordings no CME-Levels of Synovial Fluid Cytokines Predict Midterm Patient Reported Outcomes Following Arthroscopic Partial Meniscectomy

Levels of Synovial Fluid Cytokines Predict Midterm Patient Reported Outcomes Following Arthroscopic Partial Meniscectomy

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Video Transcription

Video Summary

In this video, the speaker discusses their research on the association between the intraarticular inflammatory environment during surgery and intermediate term outcomes after arthroscopic partial meniscectomy. They evaluated synovial fluid from 50 patients who underwent the surgery, measuring concentrations of cytokines, chemokines, and growth factors. They found that increased levels of pro-inflammatory Rantes, decreased levels of interleukin-1 receptor antagonist, and increased levels of matrix metalloproteinase-3 in the synovial fluid were associated with worse pain and function at follow-up. These findings suggest that synovial fluid biomarker analysis can help predict patient response to surgical treatment. The speaker acknowledges the need for further refinement and validation of their models. The video was presented at AOSSM, with disclosures available on the Academy website.

Asset Caption

Eric Strauss, MD

Keywords

intraarticular inflammatory environment

surgery

arthroscopic partial meniscectomy

synovial fluid biomarker analysis

patient response to surgical treatment