AOSSM 2023 Annual Meeting Recordings no CME-In Vitro Effects of Triamcinolone and Methylprednisolone on the Viability and Mechanics of Native Articular Cartilage

In Vitro Effects of Triamcinolone and Methylprednisolone on the Viability and Mechanics of Native Articular Cartilage

Video Transcription

Video Summary

In this video, Dean Wang from UC Irvine discusses the chondrotoxicity of corticosteroids on articular cartilage. Previous studies have shown that corticosteroids have dose-dependent chondrotoxic effects. A randomized controlled trial published in JAMA in 2017 found that patients treated with triamcinolone had a significant loss of cartilage volume. Wang's study aimed to investigate the effects of a single one-hour exposure of methylprednisolone (MP) or triamcinolone (TA) on the viability, biochemical content, and mechanics of native articular cartilage explants. The results showed a decrease in chondrocyte viability in MP-exposed explants, while no significant difference in GAG or collagen content was observed. However, both MP and TA exposure led to a decrease in compressive and tensile mechanical properties. This suggests that single short exposures to corticosteroids may lead to mechanical vulnerabilities in articular cartilage, cautioning clinicians to be mindful when using corticosteroids in patients with healthy cartilage.

Asset Caption

Dean Wang, MD

Keywords

chondrotoxicity

corticosteroids

articular cartilage

viability

mechanical properties