AOSSM 2022 Annual Meeting Recordings - no CME-The Influence of Amniotic Suspension Allografts and Bone Marrow Aspirate Concentrate on Inflammation & Cartilage Matrix Metabolism in Osteoarthritic Chondrocytes

The Influence of Amniotic Suspension Allografts and Bone Marrow Aspirate Concentrate on Inflammation & Cartilage Matrix Metabolism in Osteoarthritic Chondrocytes

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Video Summary

In this video, the presenter discusses their study on the anti-inflammatory and disease-modifying potential of bone marrow aspirate concentrate (BMAC) and amniotic suspension allograft (ASA) in a synovium and arthritic co-culture model. They found that the application of amniotic suspension allograft decreased IL-1 levels by 50% compared to the control group, while BMAC showed no improvement. BMAC did, however, show a 20% reduction in IL-6 levels. The gene expression and histology results were inconclusive and not statistically significant. The study has limitations, including a lack of characterization of the BMAC and ASA products used. Overall, the study suggests potential benefits of BMAC and ASA in reducing certain inflammatory cytokines in arthritis. The presenter acknowledges their co-authors and grants received for the study.

Asset Caption

Adam Yanke, MD, PhD

Keywords

anti-inflammatory

disease-modifying

bone marrow aspirate concentrate

amniotic suspension allograft

synovium and arthritic co-culture model