AOSSM 2022 Annual Meeting Recordings - no CME-Serum and Urine Biomarkers for Treatment Monitoring after Meniscal Allograft Transplantation in a Preclinical Canine Model

Serum and Urine Biomarkers for Treatment Monitoring after Meniscal Allograft Transplantation in a Preclinical Canine Model

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Video Summary

The video discussed the use of serum and urine biomarkers to assess pain and functional outcomes in a preclinical model of meniscus allograft transplantation (MAT). Meniscal deficiency was highlighted as a global problem that can lead to knee osteoarthritis. MAT is a successful treatment option, but it comes with complications and high reoperation rates. The study aimed to develop prognostic and diagnostic biomarker panels based on six months of post-surgery data. The study involved 12 dogs and used different MAT techniques to provide varied outcomes. Serum and urine samples were collected at various time points, and several biomarkers were assessed. The resulting biomarker panels showed promise for predicting and diagnosing pain and function after MAT surgery. Serum biomarkers like CTX-2 and IL-8 appeared to be important for both panels. The study had limitations and further research is needed for validation and optimization.

Asset Caption

Michael Ewing, MD

Keywords

serum biomarkers

urine biomarkers

pain assessment

functional outcomes

meniscus allograft transplantation