AOSSM 2022 Annual Meeting Recordings - no CME-Senolytics and Senescent Cells in Cartilage Repair

Senolytics and Senescent Cells in Cartilage Repair

Video Transcription

Video Summary

In this video, the speaker discusses their research on regenerative medicine and osteoarthritis. They explain that the development of osteoarthritis is related to a decrease in chondrocyte ability to repair cartilage and an increase in cellular senescence. Cellular senescence refers to cells that become senescent and release inflammatory mediators, contributing to aging-related diseases. The speaker discusses the use of senolytic drugs to eliminate senescent cells and their potential to delay cartilage degeneration in animal models. They also mention clinical trials using senolytic drugs and natural supplements to treat patients with mid-osteoarthritis. The speaker concludes by discussing their team's ongoing research and collaborations with other institutions. The video transcript does not include specific credits for any specific clips or visuals used in the video.

Asset Caption

Johnny Huard, PhD

Keywords

regenerative medicine

osteoarthritis

chondrocyte

cellular senescence

senolytic drugs