So, good afternoon to everyone and thank you for having me here. In this study, we are going to present you our experience with a partial meniscus scaffold. These are our disclosures. The collagen meniscus implant is a scaffold implant that could be used for partial meniscus defect. The surgical technique is arthroscopic. You just need to prepare the defect and you can measure it with an arthroscopic ruler and then you can, according to the size, the CMI that can be sutured with usually three to five all-inside suture. The indication for the scaffold in this study included both acute lesions, usually of course irreparable lesions, and chronic meniscal deficiency, so a patient with post-meniscectomy syndrome. Of course, all the patients must have intact neurons and the defect should be partial. Axial deviation and ACL insufficiency are just relative contraindications because if you address them, then you can also perform this meniscus substitution surgery. So let's go to our material methods. So we included 156 patients. The follow-up rate was very high, 84%, and the follow-up time was 11 years and the minimum was five. The age of surgery was 42 years. As you can see, most of them were male. In 80% of the cases, we used a medial CMI and 20% a lateral one, and almost half of the patients had one or more combined procedures. These are the two endpoints of the study were surgical failure, which was defined as any reason for scapular removal, even a partial scapular removal, so infection, dislocation, uni or totem knee. And the clinical failure was defined as a patient with poor lyson or a patient requiring a second surgery due to knee pain and other symptoms. So we performed a survival analysis and we investigated all these factors if they were affecting the surgical or the clinical and surgical failure. So we investigated sex, the BMI, the age of surgery, medial versus lateral scapular, the outer base grade of cartilage lesion, and combined versus isolated procedure and also the time for meniscectomy. And these are our results. So when considering surgical failure, so scapular removal, we had an overall survival rate of 88% and we had 19 surgical failures, just one dislocation, three infections, five patients had a conversion to a meniscus transplant, six to a uni and four to a totem knee. When looking at the risk factors, actually we found that the survival of the medial CMI is 90% while the survival of the lateral scapula is 81% and this was significantly lower. So the lateral scapula performed worse compared to the medial one. And while looking at the cartilage, again, you can see at 10 years, a patient with an almost intact cartilage had a survival rate of 95% while the presence of an advanced outer base grade decreased the survival rate to 80%. And all the other factors that were investigated were not significant. When moving at the clinical and the surgical failure, we found a survival rate of 70%. So we had in total 47% of patients that failed, 19 were the surgical failure, and then we had one patient that required an ultralysis, two required HDO, three required stem cells injections and 21 had a brutal iso. We didn't consider failure patients who required hardware removal due to associated procedures such as ACI revision or osteotomy. And these are our data, so again the cartilage seems to be pretty important because you can see that the survival rate dropped from 80 to 60%. And also interesting, very interesting to us, the temporary mastectomy really matters because the survival rate from patients who had the CMI in an acute situation or patients who had the CMI in the first 10 years was very similar, while if you, when we waited more than 10 years, when we had patients referred to us after 10 years, the survival rate dropped to 58%, so the other ratio was 2.8. And the other factors were not significant also in this analysis. So as a conclusion, you can see the CMI provided satisfactory long-term results and at 10 years, almost 90% of the scaffold are still in situ. And we observed more failures on the lateral scaffold than patients with advanced cartilage status, and think about the time from anasectomy when you discuss the clinical outcomes. And I would like to thank you, all my colleagues, and that are actually friends of mine, and all my mentors that guided me and helped me, so my professor, Volker, and Freddy Fu. Thank you.

partial meniscus scaffold implant

collagen meniscus implant

surgical failure rate

advanced cartilage damage

clinical failure rate