AOSSM 2022 Annual Meeting Recordings - no CME-Peer Review and the Randomized Controlled Trial: Helping Sports Medicine Realize the Level I Hype

Peer Review and the Randomized Controlled Trial: Helping Sports Medicine Realize the Level I Hype

Video Transcription

Video Summary

The speaker begins by discussing the importance of evidence-based medicine and how randomized control trials (RCTs) are a cornerstone of this approach. However, not all RCTs are equal, and it is important to critically evaluate them to ensure the results live up to the hype. The speaker then delves into specific issues related to the review of RCTs, including balancing, table one, and the use of inappropriate p-values. They emphasize that randomization does not ensure balancing, and it is necessary to check if the randomization was successful and the groups ended up balanced. They also explain that p-values in table one do not assess balancing and should not be used as indicators of group similarity. The speaker highlights the importance of maintaining the integrity of the primary outcome and avoiding inflation of alpha through multiple hypothesis testing. They also discuss the potential application of machine learning algorithms to RCT data, noting that caution should be exercised regarding sample size, population heterogeneity, and treatment effects. The speaker concludes by noting that while the talk did not cover all aspects of RCTs, such as non-inferiority trials and treatment heterogeneity, it is important to make the most of RCT data while being mindful of its limitations. The summary is based on the transcript of a video lecture, and no specific credits were mentioned.

Asset Caption

David C. Landy, MD, PhD

Keywords

evidence-based medicine

randomized control trials

critical evaluation

group balancing

primary outcome

machine learning algorithms

limitations