AOSSM 2022 Annual Meeting Recordings - no CME-Improved Cartilage Healing with Microfracture Augmented with Fisetin & Bone Marrow Aspirate Concentrate in Acute Osteochondral Defect

Improved Cartilage Healing with Microfracture Augmented with Fisetin & Bone Marrow Aspirate Concentrate in Acute Osteochondral Defect

Back to course

Video Transcription

Video Summary

In this video, the speaker discusses the treatment of cartilage injuries using micro-fractures. They explain that while micro-fractures are often used and have benefits, there is limited evidence for older patients with larger defects. The speaker then introduces two potential improvements to micro-fracture treatment: phytocin, a flavonoid with anti-inflammatory properties, and BMAC, which has anti-inflammatory benefits. The speaker presents an experiment conducted on rabbits with osteochondral defects, where micro-fracture treatment was combined with either phytocin, BMAC, or both. The results showed that the combination of phytocin and BMAC led to better macroscopic and histological scores, indicating improved cartilage regeneration. Biomechanical analysis also showed stronger regenerated cartilage in this group. The video concludes by suggesting that phytocin may delay chondrocyte senescence and improve cartilage healing.

Asset Caption

Naomasa Fukase, MD, PhD

Keywords

cartilage injuries

micro-fractures

phytocin

BMAC

cartilage regeneration