2022 AOSSM Annual Meeting Recordings with CME-The Influence of Amniotic Suspension Allografts and Bone Marrow Aspirate Concentrate on Inflammation & Cartilage Matrix Metabolism in Osteoarthritic Chondrocytes

The Influence of Amniotic Suspension Allografts and Bone Marrow Aspirate Concentrate on Inflammation & Cartilage Matrix Metabolism in Osteoarthritic Chondrocytes

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Video Transcription

Video Summary

In this video, the speaker discusses their study on the potential anti-inflammatory and disease modifying effects of bone marrow aspirate concentrate (BMAC) and amniotic suspension allograft (ASA) in a synovium and arthritic co-culture model. The study involved 17 patients undergoing total knee arthroplasty. The results showed that the application of ASA significantly decreased IL-1 levels, while BMAC showed no improvement. BMAC did, however, reduce IL-6 levels by about 20%. Gene expression analysis showed mixed results, and histology findings were not statistically significant. The study had limitations, such as not characterizing the products used. Overall, the study suggests that BMAC and ASA may have some anti-inflammatory effects, but did not mitigate the overall disease process. Credits were given to the co-authors and organizations that supported the study.

Asset Caption

Adam Yanke, MD, PhD

Keywords

anti-inflammatory effects

disease modifying effects

bone marrow aspirate concentrate

amniotic suspension allograft

total knee arthroplasty