2022 AOSSM Annual Meeting Recordings with CME-Serum and Urine Biomarkers for Treatment Monitoring after Meniscal Allograft Transplantation in a Preclinical Canine Model

Serum and Urine Biomarkers for Treatment Monitoring after Meniscal Allograft Transplantation in a Preclinical Canine Model

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Video Transcription

Video Summary

In this video transcript summary, the speaker discusses the importance of meniscal deficiency and its impact on knee biomechanics, which can lead to knee osteoarthritis. The speaker explains that meniscal allograft transplantation (MAT) is an effective treatment for this condition, but it is not without complications. The purpose of the study was to analyze serum and urine biomarkers to assess pain and functional outcomes in a preclinical canine model after MAT surgery. The study found that certain biomarkers, such as CTX-2 and IL-8, can be used to predict and diagnose pain and function outcomes. Serum was found to be more suitable for predictive applications, while urine was better for diagnostic purposes. Further validation of these biomarker panels could help improve patient selection and rehabilitation protocols.

Asset Caption

Michael Ewing, MD

Keywords

meniscal deficiency

knee biomechanics

knee osteoarthritis

meniscal allograft transplantation

biomarkers