2022 AOSSM Annual Meeting Recordings with CME-Peer Review and the Randomized Controlled Trial: Helping Sports Medicine Realize the Level I Hype

Peer Review and the Randomized Controlled Trial: Helping Sports Medicine Realize the Level I Hype

Video Transcription

Video Summary

The video discusses the importance of randomized control trials (RCTs) in evidence-based medicine. It emphasizes the need to critically evaluate RCTs and ensure that the results live up to the hype. The video touches on balancing table one, the use of inappropriate p-values, outcomes, hypothesis testing, trial registration, within versus between group comparisons, the potential for spin, and the application of machine learning algorithms to RCT data.<br /><br />The first point made is the importance of assessing balancing after randomization in RCTs. The video stresses the need to check if the randomization was successful and if the groups are balanced. It also emphasizes that p-values in table one should not be used to assess balancing and do not tell us if the groups are balanced.<br /><br />The video then discusses the importance of protecting alpha in hypothesis testing. It explains the need to focus on between group comparisons in RCTs and the potential for inflation of alpha due to multiple analyses.<br /><br />Next, the video raises questions and considerations regarding the application of machine learning algorithms to RCT data, such as sample size, population heterogeneity, and treatment effects.<br /><br />Overall, the video highlights the importance of critical evaluation and careful interpretation of RCTs to ensure accurate and reliable clinical conclusions. No credits were provided in the transcript.

Asset Caption

David C. Landy, MD, PhD

Keywords

RCTs

balancing table one

inappropriate p-values

hypothesis testing

machine learning algorithms

assessing balancing

alpha protection