2022 AOSSM Annual Meeting Recordings with CME-Effects of Blood Type Mismatching on Functional Graft Survival after Osteochondral Allograft Transplantation

Effects of Blood Type Mismatching on Functional Graft Survival after Osteochondral Allograft Transplantation

Video Transcription

Video Summary

In this video, Jim Standard and Jimmy Cook discuss their study on fresh osteochondral allografts and the potential immune response contributing to failures. They collected data from a large registry and analyzed failures and successes, matching them for age, body mass index, and joint type. They found that ABO and RH mismatches did not impact success or failure of the grafts. However, they discovered that 66% of the failed grafts had a significant immune response. This leads them to further investigate other factors that may contribute to the immune response, such as sex mismatch. They propose techniques to minimize the immune response in future grafts and reduce failure rates.

Asset Caption

James Cook, DVM, PhD, OTSC

Keywords

fresh osteochondral allografts

immune response

failures

ABO and RH mismatches

graft success